Nanoreporter for Real-Time Monitoring of Inflammasome Activity and Targeted Therapy.

ABSTRACT: Inflammasome activation is associated with a myriad of inflammatory diseases. However, existing methods provides a limited understanding of spatiotemporal kinetics of inflammasome activation, with restricted scope for early detection of associated treatment efficacy. This limitation offers an opportunity for the development of biocompatible in-vivo inflammasome monitoring tools with translational prospects. To achieve this, they report developing a pair of lipid-based nanoparticle systems, a reporter nanoparticle consisting of a caspase-1 activatable probe alone, and a theranostic nanoparticle combining the probe with an inflammasome-inhibiting drug. This biocompatible platform enhances the probe's residence time in circulation by preventing its opsonization and allowing its sustained rele

SUBMITTER: Nandi D 

PROVIDER: S-EPMC9951342 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature