Genetic variants in BAT2 are associated with immune responsiveness to influenza vaccination.

ABSTRACT: Background: Influenza is a global public health problem for its detrimental impact on human health. Annual vaccination is the most effective prevention of influenza infection. Identifying host genetic factors associated with the responsiveness to influenza vaccines can provide clues for developing more effective influenza vaccines. In this study, we aimed to explore whether the single nucleotide polymorphisms in BAT2 are associated with the antibody responses to influenza vaccines. Method: A nested case-control study was conducted in this research. 1968 healthy volunteers were enrolled and 1,582 of them from a Chinese Han population were eligible for further research. According to the hemagglutination inhibition titers of subjects against all influenza vaccine strains, a tota

SUBMITTER: Wen S 

PROVIDER: S-EPMC9951381 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature