The genetic and evolutionary basis of gene expression variation in East Africans.

ABSTRACT:

Background

Mapping of quantitative trait loci (QTL) associated with molecular phenotypes is a powerful approach for identifying the genes and molecular mechanisms underlying human traits and diseases, though most studies have focused on individuals of European descent. While important progress has been made to study a greater diversity of human populations, many groups remain unstudied, particularly among indigenous populations within Africa. To better understand the genetics of gene regulation in East Africans, we perform expression and splicing QTL mapping in whole blood from a cohort of 162 diverse Africans from Ethiopia and Tanzania. We assess replication of these QTLs in cohorts of predominantly European ancestry and identify candidate genes under selection in human population

SUBMITTER: Kelly DE 

PROVIDER: S-EPMC9951478 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature