Whole transcriptome analysis to explore the impaired immunological features in critically ill elderly patients with sepsis.

ABSTRACT:

Background

Sepsis is a frequent complication in critically ill patients, is highly heterogeneous and is associated with high morbidity and mortality rates, especially in the elderly population. Utilizing RNA sequencing (RNA-Seq) to analyze biological pathways is widely used in clinical and molecular genetic studies, but studies in elderly patients with sepsis are still lacking. Hence, we investigated the mortality-relevant biological features and transcriptomic features in elderly patients who were admitted to the intensive care unit (ICU) for sepsis.

Methods

We enrolled 37 elderly patients with sepsis from the ICU at Taichung Veterans General Hospital. On day-1 and day-8, clinical and laboratory data, as well as blood samples, were collected for RNA-Seq analysis. We identif

SUBMITTER: Chen IC 

PROVIDER: S-EPMC9951485 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature