Depletion and activation of microglia impact metabolic connectivity of the mouse brain.

ABSTRACT:

Aim

We aimed to investigate the impact of microglial activity and microglial FDG uptake on metabolic connectivity, since microglial activation states determine FDG-PET alterations. Metabolic connectivity refers to a concept of interacting metabolic brain regions and receives growing interest in approaching complex cerebral metabolic networks in neurodegenerative diseases. However, underlying sources of metabolic connectivity remain to be elucidated.

Materials and methods

We analyzed metabolic networks measured by interregional correlation coefficients (ICCs) of FDG-PET scans in WT mice and in mice with mutations in progranulin (Grn) or triggering receptor expressed on myeloid cells 2 (Trem2) knockouts (^-/-) as well as in double mutant Grn^-/-/Trem2^-

SUBMITTER: Gnorich J 

PROVIDER: S-EPMC9951492 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature