Activation of the IL-17/TRAF6/NF-κB pathway is implicated in Aβ-induced neurotoxicity.

ABSTRACT:

Background

Neuroinflammation plays a critical role in Amyloid-β (Aβ) pathophysiology. The cytokine, interleukin-17A (IL-17) is involved in the learning and memory process in the central nervous system and its level was reported to be increased in Alzheimer's disease (AD) brain, while the effect of IL-17 on the course of Aβ has not been well defined.

Methods

Here, we used APP/PS1 mice to detect the IL-17 expression level. Primary hippocampal neurons were treated with IL-17, and immunofluorescence was used to investigate whether IL-17 induced neuron damage. At the same time, male C57BL/6 mice were injected with Aβ₄₂ to mimic the Aβ model. Then IL-17 neutralizing antibody (IL-17Ab) was used to inject into the lateral ventricle, and the Open field test, Novel Objectiv

SUBMITTER: Liu Y 

PROVIDER: S-EPMC9951515 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature