The total polyphenolic glycoside extract of Lamiophlomis rotata ameliorates hepatic fibrosis through apoptosis by TGF-β/Smad signaling pathway.

ABSTRACT:

Background

Hepatic fibrosis is characterized by the excessive deposition of extracellular matrix (ECM) which is mainly secreted by activated hepatic stellate cells (HSCs). Lamiophlomis rotata (L. rotata) was recorded to treat jaundice in the traditional Tibetan medical system with the potential of hepatoprotection. However, the bioactivities and the possible mechanism of L. rotata on hepatic fibrosis is still largely unknown.

Aim of the study

To investigate the anti-hepatic fibrosis effects of bioactivities in L. rotata and the probable mechanism of action.

Materials and methods

Herein, total polyphenolic glycosides of L. rotata (TPLR) was purified with the selectivity adsorption resin and was analyzed by ultrahigh-performance liquid chromatography coupled with time-o

SUBMITTER: Wan G 

PROVIDER: S-EPMC9951520 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature