Pan-cancer analysis of the prognostic and immunological role of SNX29: a potential target for survival and immunotherapy.

ABSTRACT:

Background

There is growing evidence that the SNX family is critical for clinical prognosis, immune infiltration and drug sensitivity in many types of tumors. The relationships between the SNX29 gene and clinical prognosis as well as pan-cancer cell infiltration and drug sensitivity have not been fully elucidated.

Methods

In the current study, we explored the correlation between SNX29 expression and 33 types of malignancies via TCGA and GTEx. The relationship between SNX29 expression and prognostic outcome in the pan-caner cohort was also analyzed. Immune infiltration, microsatellite instability, tumor mutational burden and potential therapeutic targets of SNX29 were investigated by analyzing public databases.

Results

The expression of SNX29 was found to be significan

SUBMITTER: Xu C 

PROVIDER: S-EPMC9951530 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature