The impact of iron deposition on the fear circuit of the brain in patients with Parkinson's disease and anxiety.

ABSTRACT:

Objective

Anxiety is one of the most common psychiatric symptoms of Parkinson's disease (PD), and brain iron deposition is considered to be one of the pathological mechanisms of PD. The objective of this study was to explore alterations in brain iron deposition in PD patients with anxiety compared to PD patients without anxiety, especially in the fear circuit.

Methods

Sixteen PD patients with anxiety, 23 PD patients without anxiety, and 26 healthy elderly controls were enrolled prospectively. All subjects underwent neuropsychological assessments and brain magnetic resonance imaging (MRI) examinations. Voxel-based morphometry (VBM) was used to study morphological brain differences between the groups. Quantitative susceptibility mapping (QSM), an MRI technique capable of quant

SUBMITTER: Chen K 

PROVIDER: S-EPMC9951615 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature