Tannic Acid Induces Intestinal Dysfunction and Intestinal Microbial Dysregulation in Brandt's Voles (Lasiopodomys brandtii).

ABSTRACT: Brandt's vole (Lasiopodomys brandtii) is a small herbivorous mammal that feeds on plants rich in secondary metabolites (PSMs), including tannins. However, plant defense mechanisms against herbivory by Brandt's voles are not clearly established. This study aimed to investigate the effects of dietary tannic acid (TA) on the growth performance, intestinal morphology, digestive enzyme activities, cecal fermentation, intestinal barrier function, and gut microbiota in Brandt's voles. The results showed that TA significantly hindered body weight gain, reduced daily food intake, changed the intestinal morphology, reduced digestive enzyme activity, and increased the serum zonulin levels (p < 0.05). The number of intestinal goblet and mast cells and the levels of serum cytokines and im

SUBMITTER: Gu M 

PROVIDER: S-EPMC9951651 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature