The Effect of BSCL2 Gene on Fat Deposition Traits in Pigs.

ABSTRACT: BSCL2 encodes seipin, a transmembrane endoplasmic reticulum protein associated with lipodystrophy and severe metabolic complications, including diabetes and hepatic steatosis. In pigs, BSCL2 expression increases during adipocyte differentiation. In the present study, we identified significant gene variants associated with fat deposition (FD)-related processes based on subcutaneous fat tissue RNA-seq data. In the association study, to prove our hypothesis, three Polish pig breeds were included: Złotnicka White (ZW, n = 72), Polish Landrace (PL, n = 201), and Polish Large White (PLW, n = 169). Based on variant calling analysis and χ² tests, BSCL2 mutations showing significantly different genotype/allele distribution between high- and low-f

SUBMITTER: Piorkowska K 

PROVIDER: S-EPMC9951708 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature