The polarization of microglia and infiltrated macrophages in the injured mice spinal cords: a dynamic analysis.

ABSTRACT:

Background

Following spinal cord injury (SCI), a large number of peripheral monocytes infiltrate into the lesion area and differentiate into macrophages (Mø). These monocyte-derived Mø are very difficult to distinguish from the local activated microglia (MG). Therefore, the term Mø/MG are often used to define the infiltrated Mø and/or activated MG. It has been recognized that pro-inflammatory M1-type Mø/MG play "bad" roles in the SCI pathology. Our recent research showed that local M1 cells are mainly CD45^-/lowCD68⁺CD11b⁺ in the subacute stage of SCI. Thus, we speculated that the M1 cells in injured spinal cords mainly derived from MG rather than infiltrating Mø. So far, their dynamics following SCI are not yet entirely clear.

Methods

Female

SUBMITTER: Li JL 

PROVIDER: S-EPMC9951800 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature