Putative Role of an ABC Efflux System in Aliarcobacter butzleri Resistance and Virulence.

ABSTRACT: Aliarcobacter butzleri is considered a ubiquitous microorganism and emergent pathogen, for which increasing rates of multidrug resistance have been described. In line with this, the present work aimed to evaluate for the first time the contribution of an ABC efflux system, the YbhFSR, in the resistance and virulence of this bacterium. Following the in silico characterization of the YbhFSR transporter, a mutant strain was constructed by inactivating the gene responsible for ATP-binding. After ensuring that the mutation did not have an impact on bacterial growth, the resistance profile of parental and mutant strains to different antimicrobial agents was evaluated. The results suggest that the efflux pump may influence the resistance to benzalkonium chloride, ethidium bromide, and cadm

SUBMITTER: Martins I 

PROVIDER: S-EPMC9951867 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature