Meropenem Model-Informed Precision Dosing in the Treatment of Critically Ill Patients: Can We Use It?

ABSTRACT: The number of pharmacokinetic (PK) models of meropenem is increasing. However, the daily role of these PK models in the clinic remains unclear, especially for critically ill patients. Therefore, we evaluated the published meropenem models on real-world ICU data to assess their suitability for use in clinical practice. All models were built in NONMEM and evaluated using prediction and simulation-based diagnostics for the ability to predict the subsequent meropenem concentrations without plasma concentrations (a priori), and with plasma concentrations (a posteriori), for use in therapeutic drug monitoring (TDM). Eighteen PopPK models were included for evaluation. The a priori fit of the models, without the use of plasma concentrations, was poor, with a prediction error (PE)% of the interquar

SUBMITTER: Li L 

PROVIDER: S-EPMC9951903 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature