RAAV Manufacturing: The Challenges of Soft Sensing during Upstream Processing.

ABSTRACT: Recombinant adeno-associated virus (rAAV) is the most effective viral vector technology for directly translating the genomic revolution into medicinal therapies. However, the manufacturing of rAAV viral vectors remains challenging in the upstream processing with low rAAV yield in large-scale production and high cost, limiting the generalization of rAAV-based treatments. This situation can be improved by real-time monitoring of critical process parameters (CPP) that affect critical quality attributes (CQA). To achieve this aim, soft sensing combined with predictive modeling is an important strategy that can be used for optimizing the upstream process of rAAV production by monitoring critical process variables in real time. However, the development of soft sensors for rAAV production as a fa

SUBMITTER: Iglesias CF 

PROVIDER: S-EPMC9951952 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature