Critical Role of the Sulfiredoxin-Peroxiredoxin IV Axis in Urethane-Induced Non-Small Cell Lung Cancer.

ABSTRACT: Non-small cell lung cancer (NSCLC), the most common type of lung cancer, etiologically associates with tobacco smoking which mechanistically contributes to oxidative stress to facilitate the occurrence of mutations, oncogenic transformation and aberrantly activated signaling pathways. Our previous reports suggested an essential role of Sulfiredoxin (Srx) in promoting the development of lung cancer in humans, and was causally related to Peroxiredoxin IV (Prx4), the major downstream substrate and mediator of Srx-enhanced signaling. To further explore the role of the Srx-Prx4 axis in de novo lung tumorigenesis, we established Prx4^-/- and Srx^-/-/Prx4^-/- mice in pure FVB/N background. Together with wild-type litter mates, these mice were exposed to carcinogenic

SUBMITTER: Hao Y 

PROVIDER: S-EPMC9951953 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature