Age-Dependent Skeletal Muscle Mitochondrial Response to Short-Term Increased Dietary Fructose.

ABSTRACT: The harmful effect of a long-term high-fructose diet is well established, but the age-dependent physiological responses that can be triggered by a short-term high-fructose diet in skeletal muscles have not been deeply explored. Therefore, the aim of this work was to compare the alterations in mitochondrial energetic and insulin responsiveness in the skeletal muscle induced by a short-term (2 weeks) fructose feeding in rats of different ages. For this purpose, fructose and uric acid levels, insulin sensitivity, mitochondrial bioenergetics and oxidative status were evaluated in the skeletal muscles from young (30 days old) and adult (90 days old) rats. We showed that, even in the short term, a high-fructose diet has a strong impact on skeletal muscle metabolism, with more marked effects in y

SUBMITTER: Gatto C 

PROVIDER: S-EPMC9951991 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature