Methionine Sulfoxide Reductases Suppress the Formation of the [PSI⁺] Prion and Protein Aggregation in Yeast.

ABSTRACT: Prions are self-propagating, misfolded forms of proteins associated with various neurodegenerative diseases in mammals and heritable traits in yeast. How prions form spontaneously into infectious amyloid-like structures without underlying genetic changes is poorly understood. Previous studies have suggested that methionine oxidation may underlie the switch from a soluble protein to the prion form. In this current study, we have examined the role of methionine sulfoxide reductases (MXRs) in protecting against de novo formation of the yeast [PSI⁺] prion, which is the amyloid form of the Sup35 translation termination factor. We show that [PSI⁺] formation is increased during normal and oxidative stress conditions in mutants lacking either one of the yeast MX

SUBMITTER: Schepers J 

PROVIDER: S-EPMC9952077 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature