Quinolone Resistance Genes and Their Contribution to Resistance in Vibrio cholerae Serogroup O139.

ABSTRACT:

Background

Quinolones are commonly used for reducing the duration of diarrhea, infection severity, and limiting further transmission of disease related to Vibrio cholerae, but V. cholerae susceptibility to quinolone decreases over time. In addition to mutations in the quinolone-resistance determining regions (QRDRs), the presence of qnr and other acquired genes also contributes to quinolone resistance.

Results

We determined the prevalence of quinolone resistance related genes among V. cholerae O139 strains isolated in China. We determined that eight strains carried qnrVC, which encodes a pentapeptide repeat protein of the Qnr subfamily, the members of which protect topoisomerases from quinolone action. Four qnrVC alleles were detecte

SUBMITTER: Zhou YY 

PROVIDER: S-EPMC9952142 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature