Induction of Endogenous Antimicrobial Peptides to Prevent or Treat Oral Infection and Inflammation

ABSTRACT: Antibiotics are often used to treat oral infections. Unfortunately, excessive antibiotic use can adversely alter oral microbiomes and promote the development of antibiotic-resistant microorganisms, which can be difficult to treat. An alternate approach could be to induce the local transcription and expression of endogenous oral antimicrobial peptides (AMPs). To assess the feasibility and benefits of this approach, we conducted literature searches to identify (i) the AMPs expressed in the oral cavity; (ii) the methods used to induce endogenous AMP expression; and (iii) the roles that expressed AMPs may have in regulating oral inflammation, immunity, healing, and pain. Search results identified human neutrophil peptides (HNP), human beta defensins (HBD), and cathelicidin AMP (CAMP) gene prod

SUBMITTER: Morio K 

PROVIDER: S-EPMC9952314 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature