Mutations Related to Antibiotics Resistance in Helicobacter pylori Clinical Isolates from Bangladesh.

ABSTRACT: Current management of gastric inflammation involves the eradication of Helicobacter pylori. However, the effectiveness of commonly used antibiotics against H. pylori infection has decreased due to antibiotic resistance. Phenotypic-based diagnostics are laborious and finding the cause of resistance can be difficult. Therefore, early detection and understanding of the underlying mechanism of this resistance are necessary. This study evaluated the mutations in the genes related to the Antimicrobial Resistance (AMR) of the clinical isolates from Bangladeshi subjects. Whole-genome sequencing was performed on 56 isolates and the genes (such as pbp1a, rdxA, ribF, fur, gyrA, gyrB, 23S rRNA, and infB) were extracted. The reads we

SUBMITTER: Fauzia KA 

PROVIDER: S-EPMC9952455 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature