Melanoma Cellular Signaling Transduction Pathways Targeted by Polyphenols Action Mechanisms.

ABSTRACT: Melanoma is the most aggressive type of skin cancer. Although different anti-melanoma treatments are available, their efficacy is still improvable, and the number of deaths continues to increase worldwide. A promising source of antitumor agents could be presented by polyphenols-natural plant-based compounds. Over the past decades, many studies have described multiple anticancer effects of polyphenols in melanoma, presenting their potential interactions with targeted molecules from different signaling pathways. However, to our knowledge, there is no comprehensive review on polyphenols-regulated mechanisms in melanoma cells available in the literature. To fulfill this gap, this article aims to summarize the current knowledge of molecular mechanisms of action regulated by polyphenols involved

SUBMITTER: Isacescu E 

PROVIDER: S-EPMC9952468 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature