Structural Optimization of Cannabidiol as Multifunctional Cosmetic Raw Materials.

ABSTRACT: Cannabidiol (CBD), derived from the plant cannabis, can be used in the cosmetics industry for its antioxidant, anti-inflammatory, anti-wrinkle and whitening effects. However, CBD is purified from the hemp plant extract, its source is very limited and under strict control. So in this study, computational and experimental methods were combined to search for novel CBD substitutes with high biology potencies. The action mode between CBD and target protein cannabidiol receptor 1 was studied to find the key skeleton, which was used to virtually screen a natural products database to search for compounds with 70% similarity. The hit compounds with high docking scores were selected for the ABTS and DPPH free radical scavenging experiments for antioxidant evaluation. The effects on the expressions o

SUBMITTER: Chen X 

PROVIDER: S-EPMC9952480 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature