On the Chemical and Biological Characteristics of Multifunctional Compounds for the Treatment of Parkinson's Disease.

ABSTRACT: Protein aggregation, mitochondrial dysfunction, iron dyshomeostasis, increased oxidative damage and inflammation are pathognomonic features of Parkinson's disease (PD) and other neurodegenerative disorders characterized by abnormal iron accumulation. Moreover, the existence of positive feed-back loops between these pathological components, which accelerate, and sometimes make irreversible, the neurodegenerative process, is apparent. At present, the available treatments for PD aim to relieve the symptoms, thus improving quality of life, but no treatments to stop the progression of the disease are available. Recently, the use of multifunctional compounds with the capacity to attack several of the key components of neurodegenerative processes has been proposed as a strategy to slow down the p

SUBMITTER: Garcia-Beltran O 

PROVIDER: S-EPMC9952574 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature