<i>Klebsiella pneumonia</i> in Sudan: Multidrug Resistance, Polyclonal Dissemination, and Virulence.

ABSTRACT: The emergence and global expansion of hyper-virulent and multidrug resistant (MDR) Klebsiella pneumoniae is an increasing healthcare threat worldwide. The epidemiology of MDR K. pneumoniae is under-characterized in many parts of the world, particularly Africa. In this study, K. pneumoniae isolates from hospitals in Khartoum, Sudan, have been whole-genome sequenced to investigate their molecular epidemiology, virulence, and resistome profiles. Eighty-six K. pneumoniae were recovered from patients in five hospitals in Khartoum between 2016 and 2020. Antimicrobial susceptibility was performed by disk-diffusion and broth microdilution. All isolates underwent whole genome sequencing using Illumina MiSeq; cgMLST was determined using Ridom SeqSphere+, and 7-loci MLST v

SUBMITTER: Osman EA 

PROVIDER: S-EPMC9952582 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature