Antiviral Activity of Luteolin against Pseudorabies Virus In Vitro and In Vivo.

ABSTRACT: Pseudorabies virus (PRV) can cause acute swine disease leading to economic losses worldwide and is a potential causative agent of viral encephalitis in humans. Although effective vaccines are available, an increasing number of variants have emerged in China, and identifying effective antiviral agents against PRV to prevent latent infection is essential. In this study, we assessed the antiviral activity of luteolin against PRV in vitro and in vivo. Luteolin was found to significantly inhibit PRV at a noncytotoxic concentration (70 μM), with an IC₅₀ of 26.24 μM and a selectivity index of 5.64. Luteolin inhibited the virus at the replication stage and decreased the expression of viral mRNA and gB protein. Luteolin reduced the apoptosis of PRV-infected cells, improved the survival r

SUBMITTER: Men X 

PROVIDER: S-EPMC9952634 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature