Early-Life Antibiotic Exposure and Childhood Asthma Trajectories: A National Population-Based Birth Cohort.

ABSTRACT:

Introduction

Early-life antibiotic exposure is common and impacts the development of the child's microbiome and immune system. Information on the impacts of early-life antibiotics exposure on childhood asthma is lacking.

Methods

This study examined associations between early-life (0-24 months) antibiotics exposure with childhood (6-15 years) asthma trajectories through the Australian Longitudinal Study of Australian Children (LSAC) and their linked data from the Pharmaceutical Benefits Scheme. Asthma phenotypes were derived by group-based trajectory modeling.

Results

Of 5107 LSAC participants, 4318 were included in the final analyses (84.6% retention). Four asthma phenotypes were identified: Always-low-risk (79.0%), early-resolving asthma (7.1%), early-persistent asth

SUBMITTER: Lu Y 

PROVIDER: S-EPMC9952656 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature