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NO and Heme Proteins: Cross-Talk between Heme and Cysteine Residues.

ABSTRACT: Heme proteins are a diverse group that includes several unrelated families. Their biological function is mainly associated with the reactivity of the heme group, which-among several other reactions-can bind to and react with nitric oxide (NO) and other nitrogen compounds for their production, scavenging, and transport. The S-nitrosylation of cysteine residues, which also results from the reaction with NO and other nitrogen compounds, is a post-translational modification regulating protein activity, with direct effects on a variety of signaling pathways. Heme proteins are unique in exhibiting this dual reactivity toward NO, with reported examples of cross-reactivity between the heme and cysteine residues within the same protein. In this work, we review the literature on this interplay, with particular emphasis on heme proteins in which heme-dependent nitrosylation has been reported and those for which both heme nitrosylation and S-nitrosylation have been associated with biological functions.

SUBMITTER: Verde C

PROVIDER: S-EPMC9952723 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature

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NO and Heme Proteins: Cross-Talk between Heme and Cysteine Residues.

Verde Cinzia C Giordano Daniela D Bruno Stefano S

Antioxidants (Basel, Switzerland) 20230130 2

Heme proteins are a diverse group that includes several unrelated families. Their biological function is mainly associated with the reactivity of the heme group, which-among several other reactions-can bind to and react with nitric oxide (NO) and other nitrogen compounds for their production, scavenging, and transport. The S-nitrosylation of cysteine residues, which also results from the reaction with NO and other nitrogen compounds, is a post-translational modification regulating protein activi ...[more]

PMID: 36829880

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