Design of a multi-epitope vaccine against six Nocardia species based on reverse vaccinology combined with immunoinformatics.

ABSTRACT:

Background

Nocardia genus, a complex group of species classified to be aerobic actinomycete, can lead to severe concurrent infection as well as disseminated infection, typically in immunocompromised patients. With the expansion of the susceptible population, the incidence of Nocardia has been gradually growing, accompanied by increased resistance of the pathogen to existing therapeutics. However, there is no effective vaccine against this pathogen yet. In this study, a multi-epitope vaccine was designed against the Nocardia infection using reverse vaccinology combined with immunoinformatics approaches.

Methods

First, the proteomes of 6 Nocardia subspecies Nocardia subspecies (Nocardia farcinica, Nocardia cyriacigeorgica, Nocardia abscessus, Nocardia otitidiscaviarum,

SUBMITTER: Zhu F 

PROVIDER: S-EPMC9952739 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature