Exploiting Multi-Omics Profiling and Systems Biology to Investigate Functions of TOMM34.

ABSTRACT: Although modern biology is now in the post-genomic era with vastly increased access to high-quality data, the set of human genes with a known function remains far from complete. This is especially true for hundreds of mitochondria-associated genes, which are under-characterized and lack clear functional annotation. However, with the advent of multi-omics profiling methods coupled with systems biology algorithms, the cellular role of many such genes can be elucidated. Here, we report genes and pathways associated with TOMM34, Translocase of Outer Mitochondrial Membrane, which plays role in the mitochondrial protein import as a part of cytosolic complex together with Hsp70/Hsp90 and is upregulated in various cancers. We identified genes, proteins, and metabolites altered in TOMM34<

SUBMITTER: Poverennaya EV 

PROVIDER: S-EPMC9952762 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature