The Role of MMPs in the Era of CFTR Modulators: An Additional Target for Cystic Fibrosis Patients?

ABSTRACT: Cystic fibrosis (CF) is a high-prevalence disease characterized by significant lung remodeling, responsible for high morbidity and mortality worldwide. The lung structural changes are partly due to proteolytic activity associated with inflammatory cells such as neutrophils and macrophages. Matrix metalloproteases (MMPs) are the major proteases involved in CF, and recent literature data focused on their potential role in the pathogenesis of the disease. In fact, an imbalance of proteases and antiproteases was observed in CF patients, resulting in dysfunction of protease activity and loss of lung homeostasis. Currently, many steps forward have been moved in the field of pharmacological treatment with the recent introduction of triple-combination therapy targeting the CFTR channel. Despite CF

SUBMITTER: Esposito R 

PROVIDER: S-EPMC9952876 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature