Correlates of Taxane-Induced Neuropathy, an Electronic Health Record Based Observational Study.

ABSTRACT:

Background

Chemotherapy-induced peripheral neuropathy (CIPN) is a common therapeutic complication affecting cancer patients' quality-of-life. We evaluated clinical characteristics, demographics, and lifestyle factors in association with CIPN following taxane treatment.

Methods

Data were extracted from the electronic health record of 3387 patients diagnosed with a primary cancer and receiving taxane (i.e., paclitaxel or docetaxel) at Vanderbilt University Medical Center. Neuropathy was assessed via a validated computer algorithm. Univariate and multivariate regression models were applied to evaluate odds ratios (ORs) and 95% confidence intervals (CIs) of CIPN-associated factors.

Results

Female sex (OR = 1.28, 95% CI = 1.01-1.62), high body-mass index (BMI) (OR = 1.31,

SUBMITTER: Dorand RD 

PROVIDER: S-EPMC9952888 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature