TMPRSS2 Impacts Cytokine Expression in Murine Dendritic Cells.

ABSTRACT:

Background

The transmembrane protease serine 2 (TMPRSS2) proteolytically activates the envelope proteins of several viruses for viral entry via membrane fusion and is therefore an interesting and promising target for the development of broad-spectrum antivirals. However, the use of a host protein as a target may lead to potential side effects, especially on the immune system. We examined the effect of a genetic deletion of TMPRSS2 on dendritic cells.

Methods

Bone marrow cells from wild-type (WT) and TMPRSS2-deficient mice (TMPRSS2^-/-) were differentiated to plasmacytoid dendritic cells (pDCs) and classical DCs (cDCs) and activated with various toll-like receptor (TLR) agonists. We analyzed the released cytokines and the mRNA expression of chemokine receptor

SUBMITTER: Gunne S 

PROVIDER: S-EPMC9952936 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature