Preparation, Characterization of New Antimicrobial Antitumor Hybrid Semi-Organic Single Crystals of Proline Amino Acid Doped by Silver Nanoparticles.

ABSTRACT: Proline is water soluble amino acid extensively used in drug delivery systems. Compounds of cobalt (Co) transition metal have potent antimicrobial and anticancer activities. However, a drug delivery system combining proline cobalt is not reported yet. For the first time, new hybrid semi-organic single crystals of proline cobalt chloride (PCC) are prepared. The novelty of the article is also that single crystal proline cobalt chloride showed potent antimicrobial and antitumor activity. Doping of PCC by Ag⁰NPs significantly increased these biological activities. The anisotropic magnetic properties of single crystals can mitigate the cytotoxicity of Ag⁰NPs on normal cells. Silver nanoparticles (Ag⁰NPs) improved the crystal habits and physicochemical properties

SUBMITTER: Almufarij RS 

PROVIDER: S-EPMC9952970 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature