The Matricellular Protein Hevin Is Involved in Alcohol Use Disorder.

ABSTRACT: Astrocytic-secreted matricellular proteins have been shown to influence various aspects of synaptic function. More recently, they have been found altered in animal models of psychiatric disorders such as drug addiction. Hevin (also known as Sparc-like 1) is a matricellular protein highly expressed in the adult brain that has been implicated in resilience to stress, suggesting a role in motivated behaviors. To address the possible role of hevin in drug addiction, we quantified its expression in human postmortem brains and in animal models of alcohol abuse. Hevin mRNA and protein expression were analyzed in the postmortem human brain of subjects with an antemortem diagnosis of alcohol use disorder (AUD, n = 25) and controls (n = 25). All the studied brain regions (prefrontal co

SUBMITTER: Nunez-delMoral A 

PROVIDER: S-EPMC9953008 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature