The Constitutive Activity of Spinal 5-HT₆ Receptors Contributes to Diabetic Neuropathic Pain in Rats.

ABSTRACT: Diabetic neuropathy is often associated with chronic pain. Serotonin type 6 (5-HT₆) receptor ligands, particularly inverse agonists, have strong analgesic potential and may be new candidates for treating diabetic neuropathic pain and associated co-morbid cognitive deficits. The current study addressed the involvement of 5-HT₆ receptor constitutive activity and mTOR signaling in an experimental model of diabetic neuropathic pain induced by streptozocin (STZ) injection in the rat. Here, we show that mechanical hyperalgesia and associated cognitive deficits are suppressed by the administration of 5-HT₆ receptor inverse agonists or rapamycin. The 5-HT₆ receptor ligands also reduced tactile allodynia in traumatic and toxic neuropathic pain induced by

SUBMITTER: Mokhtar N 

PROVIDER: S-EPMC9953062 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature