Effect of Zbed6 Single-Allele Knockout on the Growth and Development of Skeletal Muscle in Mice.

ABSTRACT: ZBED6, a key transcription factor, plays an important role in skeletal muscle and organ growth. ZBED6 knockout (ZBED6^-/-) leads to the upregulation of IGF2 in pig and mice muscle, thereby increasing muscle mass. However, the effects and mechanism of Zbed6 single-allele knockout (Zbed6^+/-) on mice muscle remain unknown. Here, we reported that Zbed6^+/- promotes muscle growth by a new potential target gene rather than Igf2 in mice muscle. Zbed6^+/- mice showed markedly higher muscle mass (25%) and a markedly higher muscle weight ratio (18%) than wild-type (WT) mice, coinciding with a larger muscle fiber area (28%). Despite a significant increase in muscle growth, Zbed6^+/- mice showed

SUBMITTER: Liu L 

PROVIDER: S-EPMC9953215 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature