SDF-1α-Releasing Microspheres Effectively Extend Stem Cell Homing after Myocardial Infarction.

ABSTRACT: Ischemic heart disease (IHD) is one of the main focuses in today's healthcare due to its implications and complications, and it is predicted to be increasing in prevalence due to the ageing population. Although the conventional pharmacological and interventional methods for the treatment of IHD presents with success in the clinical setting, the long-term complications of cardiac insufficiency are on a continual incline as a result of post-infarction remodeling of the cardiac tissue. The migration and involvement of stem cells to the cardiac muscle, followed by differentiation into cardiac myocytes, has been proven to be the natural process, though at a slow rate. SDF-1α is a novel candidate to mobilize stem cells homing to the ischemic heart. Endogenous SDF-1α levels are elevated after myo

SUBMITTER: Bajdak-Rusinek K 

PROVIDER: S-EPMC9953248 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature