Autopsies Revealed Pathological Features of COVID-19 in Unvaccinated vs. Vaccinated Patients.

ABSTRACT: Background: In Italy, by the end of 2021, a new pandemic wave led to increased hospitalizations and death, even in some vaccinated people. We aimed to investigate the death of COVID-19-vaccinated patients who acquired infection and developed severe disease, and to assess differences with fatal COVID-19 in unvaccinated subjects by studying the pathological events triggered by SARS-CoV-2. Methods: Detailed autoptic examination was performed on five fully vaccinated compared to five unvaccinated patients. Histopathological analysis focused on the lung and heart, the two major affected organs. Results: COVID-19 caused, or contributed to death, in all the unvaccinated cases. By contrast, in vaccinated group, pre-existing pathologies played a major role, and death was not CO

SUBMITTER: Colombo D 

PROVIDER: S-EPMC9953314 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature