Hyperactivation of p21-Activated Kinases in Human Cancer and Therapeutic Sensitivity.

ABSTRACT: Over the last three decades, p21-activated kinases (PAKs) have emerged as prominent intracellular nodular signaling molecules in cancer cells with a spectrum of cancer-promoting functions ranging from cell survival to anchorage-independent growth to cellular invasiveness. As PAK family members are widely overexpressed and/or hyperactivated in a variety of human tumors, over the years PAKs have also emerged as therapeutic targets, resulting in the development of clinically relevant PAK inhibitors. Over the last two decades, this has been a promising area of active investigation for several academic and pharmaceutical groups. Similar to other kinases, blocking the activity of one PAK family member leads to compensatory activity on the part of other family members. Because PAKs are also activ

SUBMITTER: Sankaran D 

PROVIDER: S-EPMC9953343 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature