Mitochondrial Neurodegeneration: Lessons from Drosophila melanogaster Models.

ABSTRACT: The fruit fly-i.e., Drosophila melanogaster-has proven to be a very useful model for the understanding of basic physiological processes, such as development or ageing. The availability of straightforward genetic tools that can be used to produce engineered individuals makes this model extremely interesting for the understanding of the mechanisms underlying genetic diseases in physiological models. Mitochondrial diseases are a group of yet-incurable genetic disorders characterized by the malfunction of the oxidative phosphorylation system (OXPHOS), which is the highly conserved energy transformation system present in mitochondria. The generation of D. melanogaster models of mitochondrial disease started relatively recently but has already provided relevant information about th

SUBMITTER: Brischigliaro M 

PROVIDER: S-EPMC9953451 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature