In Silico, In Vitro, and Ex Vivo Biological Activity of Some Novel Mebeverine Precursors.

ABSTRACT: Irritable bowel syndrome (IBS) is a functional gastroenterological disorder with complex pathogenesis and multifaceted therapy approaches, aimed at alleviating clinical symptoms and improving the life quality of patients. Its treatment includes dietary changes and drugs from various pharmacological groups such as antidiarrheals, anticholinergics, serotonin receptor antagonists, targeting chloride ion channels, etc. The present article is focused on the synthesis and biological evaluation of some mebeverine precursors as potential antispasmodics.

Methods

In silico analysis aimed at predicting the pharmacodynamic profile of the compounds was performed. Based on these predictions, ex vivo bioelectrical activity (BEA) and immunohistochemical effects of the compounds were established. A

SUBMITTER: Milusheva M 

PROVIDER: S-EPMC9953468 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature