Blood ACE Phenotyping for Personalized Medicine: Revelation of Patients with Conformationally Altered ACE.

ABSTRACT: Background: The angiotensin-converting enzyme (ACE) metabolizes a number of important peptides participating in blood pressure regulation and vascular remodeling. Elevated blood ACE is a marker for granulomatous diseases and elevated ACE expression in tissues is associated with increased risk of cardiovascular diseases. Objective and Methodology: We applied a novel approach -ACE phenotyping-to find a reason for conformationally impaired ACE in the blood of one particular donor. Similar conformationally altered ACEs were detected previously in 2-4% of the healthy population and in up to 20% of patients with uremia, and were characterized by significant increase in the rate of angiotensin I hydrolysis. Principal findings: This donor has (1) significantly increased level

SUBMITTER: Danilov SM 

PROVIDER: S-EPMC9953529 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature