Progress in Investigational Agents Targeting Serotonin-6 Receptors for the Treatment of Brain Disorders.

ABSTRACT: Serotonin (5-HT) plays an important role in the regulation of several basic functions of the central and peripheral nervous system. Among the 5-HT receptors, serotonin-6 (5-HT₆) receptor has been an area of substantial research. 5-HT₆ receptor is a G-protein-coupled receptor mediating its effects through diverse signaling pathways. Exceptional features of the receptors fueling drug discovery efforts include unique localization and specific distribution in the brain regions having a role in learning, memory, mood, and behavior, and the affinity of several clinically used psychotropic agents. Although non-clinical data suggest that both agonist and antagonist may have similar behavioral effects, most of the agents that entered clinical evaluation were antagonists. Schiz

SUBMITTER: Nirogi R 

PROVIDER: S-EPMC9953539 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature