KinFams: De-Novo Classification of Protein Kinases Using CATH Functional Units.

ABSTRACT: Protein kinases are important targets for treating human disorders, and they are the second most targeted families after G-protein coupled receptors. Several resources provide classification of kinases into evolutionary families (based on sequence homology); however, very few systematically classify functional families (FunFams) comprising evolutionary relatives that share similar functional properties. We have developed the FunFam-MARC (Multidomain ARchitecture-based Clustering) protocol, which uses multi-domain architectures of protein kinases and specificity-determining residues for functional family classification. FunFam-MARC predicts 2210 kinase functional families (KinFams), which have increased functional coherence, in terms of EC annotations, compared to the widely used KinBase cl

SUBMITTER: Adeyelu T 

PROVIDER: S-EPMC9953599 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature