Raised FGF23 Correlates to Increased Mortality in Critical Illness, Independent of Vitamin D.

ABSTRACT:

Background

Fibroblast Growth Factor (FGF23) is an endocrine hormone classically associated with the homeostasis of vitamin D, phosphate, and calcium. Elevated serum FGF23 is a known independent risk factor for mortality in chronic kidney disease (CKD) patients. We aimed to determine if there was a similar relationship between FGF23 levels and mortality in critically ill patients.

Methods

Plasma FGF23 levels were measured by ELISA in two separate cohorts of patients receiving vitamin D supplementation: critical illness patients (VITdAL-ICU trial, n = 475) and elective oesophagectomy patients (VINDALOO trial, n = 76). Mortality data were recorded at 30 and 180 days or at two years, respectively. FGF23 levels in a healthy control cohort were also measured (n

SUBMITTER: Thein OS 

PROVIDER: S-EPMC9953634 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature