G_q-Mediated Arrhythmogenic Signaling Promotes Atrial Fibrillation.

ABSTRACT:

Background

Atrial fibrillation (AF) is promoted by various stimuli like angiotensin II, endothelin-1, epinephrine/norepinephrine, vagal activation, or mechanical stress, all of which activate receptors coupled to G-proteins of the Gα_q/Gα₁₁-family (G_q). Besides pro-fibrotic and pro-inflammatory effects, G_q-mediated signaling induces inositol trisphosphate receptor (IP₃R)-mediated intracellular Ca²⁺ mobilization related to delayed after-depolarisations and AF. However, direct evidence of arrhythmogenic G_q-mediated signaling is absent.

Methods and results

To define the role of G_q in AF, transgenic mice with tamoxifen-inducible, cardiomyocyte-specific Gα_q/Gα₁₁-deficiency

SUBMITTER: Hohendanner F 

PROVIDER: S-EPMC9953645 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature