Whole-Blood Gene Expression Profiles Associated with Mortality in Community-Acquired Pneumonia.

ABSTRACT: (1) Background: Information regarding gene expression profiles and the prognosis of community-acquired pneumonia (CAP) is scarce. We aimed to examine the differences in the gene expression profiles in peripheral blood at hospital admission between patients with CAP who died during hospitalization and those who survived. (2) Methods: This is a multicenter study of nonimmunosuppressed adult patients who required hospitalization for CAP. Whole blood samples were obtained within 24 h of admission for genome-expression-profile analysis. Gene expression profiling identified both differentially expressed genes and enriched gene sets. (3) Results: A total of 198 samples from adult patients who required hospitalization for CAP were processed, of which 13 were from patients who died. Comparison of g

SUBMITTER: Viasus D 

PROVIDER: S-EPMC9953679 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature