Bacterial Quorum-Sensing Peptides as Immune Modulators Present in Systemic Circulation.

ABSTRACT: Quorum-sensing peptides (QSPs) are bacterial peptides traditionally considered only as inter-bacterial communication molecules. Recently, their involvement in microbiome-host interactions influencing host diseases such as cancer and sarcopenia were explored. However, it is still unknown to what extent these peptides have the potential to modulate the immune system. In this proof-of-concept study, we screened 89 QSPs for their potential to induce IL-6 and TNFα in murine splenocytes and J774 macrophages. Confirmatory experiments on the positive screening-hits were conducted using murine splenocytes and human PBMCs of different ages. Finally, to investigate the biological relevance of immunomodulatory QSPs, we analysed plasma in a human cohort for the presence of the immunomodulatory QSP Q010

SUBMITTER: De Spiegeleer A 

PROVIDER: S-EPMC9953703 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature