Human Xylosyltransferase I-An Important Linker between Acute Senescence and Fibrogenesis.

ABSTRACT: The human xylosyltransferase isoform XT-I catalyzes the initial step in proteoglycan biosynthesis and represents a biomarker of myofibroblast differentiation. Furthermore, XT-I overexpression is associated with fibrosis, whereby a fibrotic process initially develops from a dysregulated wound healing. In a physiologically wound healing process, extracellular matrix-producing myofibroblasts enter acute senescence to protect against fibrosis. The aim of this study was to determine the role of XT-I in acute senescent proto-myofibroblasts. Normal human dermal fibroblasts were seeded in a low cell density to promote myofibroblast differentiation and treated with H₂O₂ to induce acute senescence. Initiation of the acute senescence program in human proto-myofibroblasts resulte

SUBMITTER: Schmidt V 

PROVIDER: S-EPMC9953725 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature